Items modify a character's stats, grant or modify abilities, and many other things.

Items in general are classified into a number of distinct types and groups. Some items are passive, (Im working on a Passive Guide!) which add an effect permanently to Isaac, while others only activate when used.

Items dropped in the Binding of Isaac NEVER disappear over time, a coin dropped will remain where it was dropped until you pick it up or leave the floor. A dropped item can be left in its place to be collected at a later time.

Anarchist Cookbook spawns six troll bombs around the room. Recharge: 3

Best Friend deploys a decoy Isaac that eventually explodes with an increased blast radius. Recharge: 3

Blank Card has the same effect as the card or rune currently held by Isaac. Recharge: 4

Blood Rights damages all enemies in the room, but deals a half-heart of damage to Isaac with each use. Recharge: None

Bob's Rotten Head when used, Isaac holds a poison bomb which can be thrown towards any of the four cardinal points and explodes on impact. Recharge: 3

Book Of Revelations adds 1 Soul Heart and makes the next boss a Horseman (except on XL floors and floors with fixed bosses such as Mom). Recharge: 6

Book of Secrets when activated for the first time on a given floor, grants the effect of the Treasure Map. Upon being activated for the second time, grants the effects of The Compass. Upon the third activation, grants the effects of the Blue Map. All effects wear off upon moving to the next floor. Recharge: 6

Book of Shadows when used, creates a protective shield nullifying all types of damage for a short duration. Recharge: 3

Box Of Spiders summons 2-4 Blue Spiders. Recharge: 2

Breath Of Life grants a brief moment of invincibility when the charge bar hits zero. If spacebar is held for an additional second after hitting zero, Isaac will take damage. Recharge: 6 seconds

Butter Bean makes Isaac farts and pushes back nearby enemies. Recharge: 3 seconds

Converter when used, it converts two soul hearts into a heart container. Recharge: None

Crack The Sky summons multiple beams of light in random locations around the room, dealing a large amount of damage to any enemy that touches them. Recharge: 4

Crystal Ball reveals the map and drops a random Tarot Card or Soul Heart. Recharge: 6

D4 rerolls all upgrades on the player. Recharge: 6

D10 rerolls the enemies in a room. Only rerolls enemies that are still alive. Recharge: 1

D20 rerolls all pickups in the current room. Recharge: 6

D100 rerolls all passive items on Isaac like the D4, every pedestal item on the room like the D6 and every pickup like the D20. Recharge: 6

Dad's Key opens all doors in the current room, including doors which require a Key to open and entrances to secret rooms. Opens the big doors in the first room of both The Chest and The Dark Room. Recharge: 2

Dead Sea Scrolls triggers the effect of a random activated item from a list of possible options. Recharge: 3

Deck Of Cards gives Isaac a random Tarot Card. Recharge: 6

Doctor's Remote sets a big red target on the ground which can be controlled with tear controls. After 6 seconds or by pressing space again, a explosive missile hits it, which damages all enemies caught in its blast radius. Recharge: 3

Flush! changes all enemies in the room into poop. Does not work on all enemies. Recharge: 6

Forget Me Now when activated, the level ends and is freshly regenerated with new rooms, monsters, and items. Recharge: One time use

Guppy's Head spawns 2-4 Blue Flies to damage enemies. Recharge: 1

Guppy's Paw removes one Heart Container in exchange for gaining 3 Soul Hearts. Recharge: None

Head Of Krampus fires a cross-patterned brimstone shot, just like the Fallen and Krampus shoot. Recharge: 6

How To Jump gives Isaac the ability to jump. Recharge: None

Isaac's Tears shoots 8 tears around Isaac, which keep the damage, shot speed, and special effects of his tears. Each tear shot by Isaac increases item charge by one. Recharge: 6

IV Bag upon activation, Isaac loses a half-heart for a random amount of coins. Recharge: None

Kamikaze! creates an explosion in the same area as Isaac, dealing half a heart of damage to him and also damaging all enemies caught in the blast radius. Recharge: None

Lemon Mishap creates a yellow pool of Creep, which damages enemies that cross it. Recharge: 2

Magic Fingers damages all enemy in the room for one coin. Recharge: None

Mom's Bottle Of Pills gives Isaac a random Pill. Recharge: 6

Mom's Bra when used it petrifies all enemies in the current room for approximately 4 seconds. Recharge: 3

Mom's Pad when used it inflicts fear to all enemies in the room for 5 seconds. Recharge: 3

Monster Manual summons a random familiar for the current room. Can summon familiars not yet unlocked. Recharge: 4

Monstro's Tooth monstro jumps onto a random enemy, doing area damage. Recharge: 3

Mr.Boom drops a large bomb. Recharge: 2

My Little Unicorn upon use, grants invulnerability and increased speed for five seconds, removing the ability to shoot tears and instead dealing contact damage to enemies. Recharge: 6

Notched Axe will cause Isaac to hold the axe above his head for as long as the spacebar button is held (or until he leaves the room). While holding the axe, Isaac can break any rock he touches, but cannot attack or pick up other items. Recharge: 3

Pandora's Box upon use, spawns certain Pickups or Items depending on the floor it is used on. Recharge: One time use

Portable Slot upon activation, 1 coin will be consumed, and a random Pick Up may drop, similar to the Slot Machine. Recharge: None

Prayer Card grants half an Eternal Heart per use. Recharge: 6

Razor Blade upon use deals one heart damage and grants +1.2 damage for the current room. Recharge: None

Red Candle throws a persistent flame that deals high damage and diminishes as it damages enemies or blocks shots. Recharge: 4 seconds

Remote Detonator causes bombs you place explode only when you use this item, also gives 5 bombs. Recharge: None

Santanic Bible upon activation, Isaac gains a black heart. Recharge: 6

Scissors upon use, turns Isaac's head into a stationary familiar which fire the same tears as the headless body for the current room. Recharge: 6

Shoop Da Whoop! fires a laser from Isaac's mouth. Recharge: 2

Spider Butt damages all enemies in the room and slows them and their projectiles down. Recharge: 2

Tammy's Head shoots 10 tears in a circle around Isaac, which retain the damage, shot speed, and special effects. Recharge: 1

Telepathy For Dummies grants homing tears for the current room. Recharge: 2

Teleport teleports you to a random room on the level. Recharge: 2

The Bean Isaac releases bad gas, poisoning any enemy in close vicinity.Recharge: 1

The Bible upon activation, Isaac gains Flight, also instantly kills Mom, Mom's Heart, and It Lives when activated. Recharge: 6

The Book Of Belial guarantees a Devil Room or Angel Room will be open after beating a boss while holding it. Upon use increases damage by 2 for the current room.Recharge: 3

The Book Of Sin spawns a random Pick Up, Pill, Card, or Trinket. Recharge: 4

The Boomrang throws a short-range boomerang which does a bit of damage and has a high chance to stun the enemy for 2 seconds. Can also be used to grab pickups. Recharge: 4 seconds

The Candle throws out a blue flame that can pass over gaps. Recharge: 4 seconds

The D6 allows Isaac to re-roll collectible items in the current room into other items.Recharge: 6

The Gamekid turns the character into a into a Pac-Man-like creature for 5 seconds, granting invulnerability and increased speed, inflicting fear on all enemies, and replenishing half a red heart container for every two enemies killed. Recharge: 6

The Hourglass enemies and their projectiles are slowed down for a short duration. Recharge: 2

The Nail adds one Soul Heart and allows the breaking of Rocks and damaging enemies by simply walking over them. Increases Damage and decreases Speed. All effects except for the Soul Heart wear off upon leaving the room. Recharge: 6

The Necronomicon damages all enemies in the room significantly. Recharge: 6

The Pinking Shears separates Isaac's head and body for the current room. Isaac's head, which now has flight, will be under the player's control, while his body will seek out enemies to attack by contact damage. Recharge: 6

The Pony passively grants flight and increased speed. Upon use, Isaac charges in the direction the pony is facing, becoming invulnerable during the charge and damaging enemies.Recharge: 6

The Poop spawns a pile of poop where the character is standing and knocks nearby monsters back. Recharge: 1

Undefined teleports Isaac to either the Secret Room, Super Secret Room, Treasure Room, or I AM ERROR. Recharge: 6

Unicorn Stump grants invulnerability and increased speed for five seconds, but removes the ability to shoot tears. Recharge: 1

We Need To Go Deeper! creates a trapdoor to go to the next floor. Recharge: 6

White Pony passively grants flight and increased speed. Upon use, Isaac charges in the direction the pony is facing, becoming invulnerable during the charge and damaging enemies while also casting the effect of Crack The Sky. Recharge: 6

Yum Heart restores 1 whole heart. Recharge: 4

Weellllllll, hope you enjoyed the guide, and I hope it helped! Don't forget to thumb it up, and follow for more TBOIR Guides! Also, if you find any errors please comment them!


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